About the vacancy
Drug Development
About Your Next Job
We are looking for an experienced Analytical Chemistry Technician to support our progress to clinical trials in some of the deadliest solid tumor diseases.
At OncoLize we develop injectable drug depots to 'Treat Tumors from the Inside. We target direct drug delivery to some of the most difficult to treat solid tumor diseases... and with success. (www.oncolize.com)
Our Product Platform ChemoGell(TM) is based on well-known polymers that can release a broad range of established Chemo drugs at high concentrations inside tumors, while sparring the body from the typical side-effects of Chemo... And we aim at Triple A products: Affordable and Accessible for All.
Our start-up team is expanding as we approach our first clinical trials in Pancreatic Cancer. This is based on our initial successes in preclinical studies with LUMC (100% survival and no side-effects!) and other collaborations.
We currently focus on fine-tuning and finalizing our product-formulation and CMC-processing before we hand it over to Contract Development Manufacturing Organisations to make ur clinical batches.
Once that is done, we expand the portfolio to other Difficult-to-Treat solid tumor diseases by formulating other drugs and further tailoring the load and release characteristics of ChemoGell(TM).
The core technology team is established and running. Now we want to invite an experienced and self-starting analytical chemistry technician to the team to broaden our base and help us accelerate.
This is a great moment for you (and us!) to step in and help shape the future of our awesome product and company... and for the patients we ultimately do it for.
About Your Next Colleagues
We work with injectable drug formulations of small molecule drugs, peptides and polymers.
Our start-up team is a mix of pharmaceutical-, polymer- and analytical science, with expert industrial and academic experiences in building companies and products.
Ambitious, Experienced, Passionate, Open minded, Dedicated.
Dutch, Belgian, Irish and French so far. Today more women than men, but that's just who walks in the door, is curious, competent, ambitious and applies herself/himself/itself.
We collaborate closely with pre-clinical and clinical teams at LUMC and AUMC to target some of the deadliest tumor diseases, and that will expand to innovative pharma companies in the coming few years.
What unites us is the promise and the opportunity that we can make these therapies much more efficient, with far less side-effects and affordable for patients and societies.
About Your Tasks and Responsibilities
Ok, so your interested? What you will be doing initially:
· Setting up analytical methods, or making them up as we develop, and validating these.
· Formulating prototypes, with characterization and drug release studies in the lab.
· Supporting our pre-clinical and clinical partners with samples and troubleshooting in their applications as the use our products.
· Optimizing CMC-processing steps before we hand them over to CDMOs, so documenting and putting these into SOPs.
· Settijg up experiemnts to gather data for our patent applications
· Training and leading junior staff as we grow
· Organizing the lab in its formulation and analytical lay-out, equipment, maintenance, services... keeping the lab always running with smooth operations...
.... that your colleagues can take-over when you go on vacation.
About Your Skills and Experience
What does it take for you to be successful and happy in this new job?
· At least 3-5 years proven track record in analytical chemistry at drug development level, formulation development level, preferably in a pharma-company or scale-up biotech but coming from an excellent performing academic group can do the job as well.
· You know what cGLP, CMC, QA/QC and QBD is understood. Methodical, attention for detail, clear and effective reporting, ‘Gung Ho’ if need be, not just communicating about success, but als about challenges you or we face.
· Your education level is at applied technical (BSc. Dutch HBO) or scientific level (MSc. Dutch WO)
· Most important is you attitude to get the job done, whatever it takes, because we will face challenges as team, and we need all hands on deck from time to time.
· But you also need to be able to step back and think it through before you engage, ask and give input when needed.
· It is essential that you have extensive analytical experience with some of the following: UPLC/HPLC's, GPC, DSC, rheometer/viscosity/lyophilization/sterilization/ electronic data management, cGLP environment...
About Your Benefits
Well, we offer Euro 3.750-4.500 gross monthly to start with, depending on your experience and track record.
Sorry, no pension fund yet (should come later at Series A), but we do offer up to 3 months performance bonus at company level.
Compensation for commuting 1st class, and once we can, we will pay for your sports or leisure subscription...
Training in advanced skills and knowledge will expand once we move into the clinical stages of the company (2027-2028).
Once you have demonstrated that you are part of our core team from year 3 onwards, you will be offered long-term success incentives such as options to shares...
You will be exposed to clinical trials, to collaborators in some of the most advanced drug development companies and academia that partner with us.
You can develop to lead small teams in product- or process development or manage the lab-operations altogether.
But like us, the biggest benefit may come from developing solutions to some of the most challenging cancer diseases that affect us all sooner or later... and keeping it affordable.
Where Molecules Meet Opportunities
just see above and belo
Only apply if...
We hope from the above that it is clear this is not a starter's job at all.
You really must demonstrate with your track record that you are up for this career challenge... and that you are really intriguid and motivated to step into such an impact opportunity.
This not 9-5, this is what you make of it.
Once we move into our Series A funding round of €10-17 million (2027), we may move back from our top-quality Utrecht lab location to Leiden Bio Science Park as this is where it all started...
And you must have an EU-working permit.
You are eligible to work in EU
We only accept applicants who are eligible to work in the EU
Contact person
Mike De Leeuw
OncoLize develops a very direct way of targeted delivery into tumors: drug depots injected directly into solid tumors to deliver the drugs where they are most effective... and keep them there.
We inject hydrogel-based drug depots using long thin needles, catheters or endscope needles to deliver genric Chemo drugs or novel innovative drugs at high concentrations inside the tumor mass, while only dosing the mass of the tumor.
Our first target, pancreatic cancer, demonstrates 100% survival in preclinical studies and no side-effects, scaling up production to cGMP and preparing for our first patient trials in 2027/2028. because we can formulate the full range of widely-used Chemo, we will expand our portfolio to other Difficult-to-Treat cancers as soon as possible.
Benefits:
1 - Increaed efficacy: up to 170x higher concentration inside the tumor mass than ever safe to do systemically.
2 - Improved Quality of Life with less side-effects: up to 70x lower total drug dose, with almost no systemic levels
3 - Triple A products: Affordable and Accessible for All, using off-the-shelf compounds with well-known Chemo drugs that are easy to compound and scale-up to clinical and commercial scale.
With our Seed A fase now finished and raising our Seed B round and Series A of in total €20 million, we expect to grow to 15-20 FTE in the coming 2-3 years.
Stay tuned!