Manufacturing Operator

• Join our fully digital Lenti Viral Vector Facility in Sassenheim, producing vectors for multiple myeloma treatment impacting 160,000 patients worldwide.
• As we prepare for commercial production in mid-2026, we’re looking for Manufacturing Operators (USP/DSP/F&F) to support cell expansion, virus production, purification, and automated filling under GMP and BSL2 conditions.
• Build your career at the forefront of innovation in a collaborative environment, with strong growth opportunities through training, mentoring, and clear career paths.

• You will join the USP, DSP, or Fill & Finish departments in Sassenheim.
• The USP department operates on a 13/7 shift roster with 19,99% shift allowance.
• The DSP department operates on a 13/7 shift roster with 19,99% shift allowance.
• The Fill & Finish department operates on a 16/7 shift roster with a 26,19% shift allowance.

• Support the installation and operation of new equipment.
• Write job breakdown sheets for training and work instructions.
• Collaborate in the execution of daily tasks and supporting activities of the department according to procedures and detailed schedule.
• Perform process and GMP documentation activities.
• Raise process deviations and notice process gaps, and tackle them.
• Train operators.
• Contribute to continuous improvement of processes and procedures.
• Work safely and compliantly in line with GMP, EHS, and quality standards.

USP responsibilities:

• Culturing and inoculation of cells in Shaker Flasks and Wave bags.
• Daily monitoring of cell cultures (cell count, pH, sampling).
• Preparing and executing transfection processes.
• Preparing process additions (e.g. Benzonase solutions).
• Harvesting and clarification of cell culture material.
• Sample handling and documentation for USP activities.

DSP responsibilities:

• Purification using Ion Exchange chromatography.
• Sterile filtration, including filter integrity testing (PUPSIT).
• Ultrafiltration and diafiltration.
• Sample handling and documentation for DSP activities.

Fill & Finish responsibilities:

• Preparation and setup of isolators and filling equipment.
• Aseptic filling in a Grade A isolator using an automated filling robot.
• Visual inspection of filled vials.
• Labelling and storage of product in controlled freezers.

• Preferably an MBO 4 or HBO in laboratory & biotechnology, biochemistry, biomedicine, process technology, allround laborant OR equivalent education level with proven experience in biotech or biopharma manufacturing.
• Hands-on expertise in a BSL2 environment, focusing on cell culture, virus propagation, purification, or Fill & Finish, adhering to GMP and EHS standards.
• Strong English communication skills, with the ability to analyse complex situations and maintain high accuracy and independence.
• Adaptable teammate with a proactive approach, ready to tackle challenges and work flexible shifts.

Preferred Skills:

• Administrative Support
• Agile Manufacturing
• Analytics Dashboards
• Chemistry, Manufacturing, and Control (CMC)
• Communication
• Data Compilation
• Data Savvy
• Execution Focus
• Gap Analysis
• Good Manufacturing Practices (GMP)
• Operational Excellence
• Plant Operations
• Process Optimization
• Process Oriented
• Project Administration
• Regulatory Compliance
• Self-Awareness

• 12-month contract incl. 1 month probation period.
• 40-hour work week, shifts to be implemented.
• 36 days of paid leave, based on a full-time contract.
• J&J Health Insurance with Zilveren Kruis Achmea.
• J&J Pension Plan.
• Commuting allowance.
• Global Well-Being Reimbursement up to 450EUR.
• Referral bonus.
• Working Jubilee Gifts.
• Global Parental leave.
• Career Opportunities to keep growing on your skills.
• Annual bonus with set target (% of pay) depending on pay grade / location, based on the employees’ and companies’ performance of the previous calendar year.
• Vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave.
• Well-being reimbursement, programs for financial, physical and mental health.
• Service anniversary and recognition awards.
• Insurance plans for employees and eligible dependents.

• At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.
• Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
• As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual.
• At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

• Preferably an MBO 4 or HBO in laboratory & biotechnology, biochemistry, biomedicine, process technology, allround laborant OR equivalent education level with proven experience in biotech or biopharma manufacturing.
• Hands-on expertise in a BSL2 environment, focusing on cell culture, virus propagation, purification, or Fill & Finish, adhering to GMP and EHS standards.